Atomic force microscopy method in the study of platelets of patients with end-stage of chronic heart failure
Abstract
Atomic force microscopy was used to estimate the intravascular platelet activation and determine local elastic modulus, adhesion and stiffness of the platelets membrane in patients with end-stage of chronic heart failure with heart ventricle implantation before surgery and intrasurgical: before the heparin injection, after the heparin injection and after neutralization of heparin with protamine.
About the Authors
L. V. Kukharenko
Белорусский государственный медицинский университет, Республика Беларусь
Belarus
Belarus
S. A. Chizhik
Белорусский государственный медицинский университет, Республика Беларусь
Belarus
Belarus
E. S. Drozd
Белорусский государственный медицинский университет, Республика Беларусь
Belarus
Belarus
M. V. Goltsev
Белорусский государственный медицинский университет, Республика Беларусь
Belarus
Belarus
N. N. Maroz-Vadalazhskaya
Белорусский государственный медицинский университет, Республика Беларусь
Belarus
Belarus
References
1. Imaging modes of atomic force microscopy for application in molecular and cell biology / Y.F. Dufrene [et al.] // Nature Nanotechnology. 2017. Vol. 12. P. 295-307. Measuring the viscoelastic properties of human platelets with the atomic force microscope / M. Radmacher [et al.] // Biophys. J. 1996. P. 556-567. Toward correlating structure and mechanics of platelets / S. Sorrentino [et al.] // Cell Adhesion and Migration. 2016. Vol. 10. P. 568-575.
Review
For citations:
Kukharenko L.V., Chizhik S.A., Drozd E.S., Goltsev M.V., Maroz-Vadalazhskaya N.N. Atomic force microscopy method in the study of platelets of patients with end-stage of chronic heart failure. Doklady BGUIR. 2018;(7):12-17. (In Russ.)
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