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USE OF AFM FOR MORPHO-FUNCTIONAL STATE DIAGNOSTICS OF PLATELETS OF PATIENTS WITH ISCHEMIC HEART DISEASE

Abstract

Atomic force microscopy was used to identify the early stages of intravascular platelet activation in patients with stable angina and in patients with unstable ischemic heart disease to characterize hemostasiological status of the patients. A comparative analysis of morpho-functional platelet parameters has shown the increase of intravascular platelet activation and the formation of spontaneous platelet aggregates in bloodstream in patients with unstable angina.

About the Authors

L. V. Kukharenko
Белорусский государственный медицинский университет
Belarus


S. A. Chizhik
Институт тепло- и массообмена им. А. В. Лыкова НАН Беларуси
Belarus


E. S. Drozd
Институт тепло- и массообмена им. А. В. Лыкова НАН Беларуси
Belarus


L. G. Gelis
Республиканский научно-практический центр «Кардиология»
Belarus


I. V. Lazareva
Республиканский научно-практический центр «Кардиология»
Belarus


E. A. Medvedeva
Республиканский научно-практический центр «Кардиология»
Belarus


References

1. Radmacher M.,. Fritz M., Kacher C.M. et. al. // Biophys. J. 1996. P. 556-567.

2. Liu X., Li Y., Zhu H. et. al. // Platelets. 2015. Vol. 26 (5). P. 480-485.

3. Sorrentino S., Studt J.-D., Horev M. et. al. // Cell Adhesion and Migration. 2016. Vol. 10. P. 568-575.


Review

For citations:


Kukharenko L.V., Chizhik S.A., Drozd E.S., Gelis L.G., Lazareva I.V., Medvedeva E.A. USE OF AFM FOR MORPHO-FUNCTIONAL STATE DIAGNOSTICS OF PLATELETS OF PATIENTS WITH ISCHEMIC HEART DISEASE. Doklady BGUIR. 2016;(7):66-70. (In Russ.)

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ISSN 1729-7648 (Print)
ISSN 2708-0382 (Online)