Electromagnetic Activation of Salicylic Acid in a Complex with Oxidized Zinc-graphene Structure
https://doi.org/10.35596/1729-7648-2023-21-1-26-34
Abstract
This work aims at the development of a method of electromagnetic activation of salicylic acid molecules per se (SA) through the ultrasonic (20 kHz) complexation with oxidized zinc-graphene structure. The result of this work implies synthesized nanopartiсles “ZnO – partially restored graphene oxide (rGO) – SA” with the average size of (5.53 ± 0.11) nm and hexagonal wurtzite zinc oxide structure with complexed SA molecules. Complexation of SA with “ZnO – rGO” matrix causes magnification of electromagnetic field of SA by 102 times with the local enhancement at the contact with ZnO by 103 times, and therefore allowing selective electromagnetic activation of drug molecules. The developed method of “ZnO – rGO – SA” nanoparticles formation can be applied to many different drugs and drug-based devices, thereby introducing a great interest in medicinal electronics and nanomedicine.
About the Authors
V. Y. Kaliskarov
Belarusian State University of Informatics and Radioelectronics
Belarus
Belarus
Diploma Student at the Department of Micro- and Nanoelectronics
220013, Minsk, P. Brovkа St., 6
Y. A. Zialkouski
Belarusian State University of Informatics and Radioelectronics
Belarus
Belarus
Student at the Department of Micro- and Nanoelectronics
220013, Minsk, P. Brovkа St., 6
D. V. Radziuk
Belarusian State University of Informatics and Radioelectronics
Belarus
Belarus
Radziuk Darya Vladimirovna, Cand. of Sci., Leading Scientist in the Research Laboratory “Integrated Micro- and Nano systems”
220013, Minsk, P. Brovkа St., 6
References
1. Rena G., Sakamoto K. (2014) Salicylic Acid: Old and New Implications for the Treatment of Type 2 diabetes? Diabetol. Int. 5 (4), 212–218. DOI: 10.1007/s13340-014-0177-8.
2. Bashir A. I. J., Kankipati C. S., Jones S., Newman R. M., Safrany S. T., Perry C. J., Nicholl I. D. (2019) A Novel Mechanism for the Anticancer Activity of Aspirin and Salicylates. Int. J. Oncol. 54 (4), 1256–1270. DOI: 10.3892/ijo.2019.4701.
3. JanoŠ P., Spinello A., Magistrato A. (2021) All-atom Simulations to Studying Metallodrugs. Target Interactions. Curr. Opin. Chem. Biol. (61), 1–8. DOI: 10.1016/j.cbpa.2020.07.005.
4. Stathopoulou M.-E. K., Banti C. N., Kourkoumelis N., Hatzidimitriou A. G., Kalampounias A. G., Hadjikakou S. K. (2018) Silver Complex of Salicylic Acid and its Hydrogel-cream in Wound Healing Chemotherapy. J Inorg. Biochem. (181), 41–55. DOI: 10.1016/j.jinorgbio.2018.01.004.
5. Banti C. N., Papatriantafyllopoulou C., Tasiopoulos A. J., Hadjikakou S. K. (2018) New Metalo-therapeutics of NSAIDs Against Human Breast Cancer Cells. Eur. J Med. Chem. (143), 1687–1701. DOI: 10.1016/j.ejmech.2017.10.067.
6. Wu X.-W., Zheng Y., Wang F.-X., Cao J.-J., Zhang H., Zhang D.-Y., Tan C.-P., Ji L.-N., Mao Z.-W. (2019) Anticancer IrIII-aspirin Conjugates for Enhanced Metabolic Immunomodulation and Mitochondrial Lifetime Imaging. Chem. Eur. J. 25 (28), 7012–7022. DOI: 10.1002/chem.201900851.
7. Deng J., Gou Y., Chen W., Fu X., Deng H. (2016) The Cu/Ligand Stoichiometry Effect on the Coordination Behavior of Aroyl Hydrazone with Copper(II): Structure, Anticancer Activity and Anticancer Mechanism. Bioorg. Med. Chem. 24 (10), 2190–2198. DOI: 10.1016/j.bmc.2016.03.033.
8. Zare M., Namratha K. (2018) Surfactant Assisted Solvothermal Synthesis of ZnO Nanoparticles and Study of their Antimicrobial and Antioxidant Properties. J Mater. Sci. Technol. 34 (6), 1035–1043. DOI: 10.1016/j.jmst.2017.09.014.
9. Widiyastuti W., Wang W.-N. (2007) A Pulse Combustion Spray Pyrolysis Process for the Preparation of Nano and Submicrometer Sized Oxide Particles. J. Am. Ceram. Soc. 90 (12), 3779–3785. DOI: /10.1111/j.15512916.2007.02045.x.
10. Saloga P. E. J., Thünemann A. F. (2019) Microwave Assisted Synthesis of Ultrasmall Zinc Oxide Nanoparticles. Langmuir. 35 (38), 12469–12482. DOI: 10.1021/acs.langmuir.9b01921.
11. Hinman J. J., Suslick K. S. (2017) Nanostructured Materials Synthesis Using Ultrasound. Top Curr. Chem. (Z). 375 (1), 59–94. DOI: 10.1007/s41061-016-0100-9.
12. Laurenti M., Lamberti A. (2019) Graphene Oxide Finely Tunes the Bioactivity and Drug Delivery of Mesoporous ZnO Scaffolds. ACS Appl. Mater. Interfaces. 11 (1), 449–456. DOI: 10.1021/acsami.8b20728.
13. Alipour N., Namazi H. (2020) Chelating ZnO-Dopamine on the Surface of Graphene Oxide and its Application as pH-Responsive and Antibacterial Nanohybrid Delivery Agent for Doxorubicin. Mater. Sci. Eng. C Mater. Biol. Appl. (108), 110459. DOI: 10.1016/j.msec.2019.110459.
14. VolovŠek V., Colombo L., Furić K. (1983) Vibrational Spectrum and Normal Coordinate Calculations of the Salicylic Acid Molecule. J Raman Spectrosc. 14 (5), 347–352. DOI: /10.1002/jrs.1250140511.
Review
For citations:
Kaliskarov V.Y., Zialkouski Y.A., Radziuk D.V. Electromagnetic Activation of Salicylic Acid in a Complex with Oxidized Zinc-graphene Structure. Doklady BGUIR. 2023;21(1):26-34. (In Russ.) https://doi.org/10.35596/1729-7648-2023-21-1-26-34
Views: 372
Email this article 