Iron-binding property of lactoferrin in the case of inflammation
Abstract
Lactoferrin (Lf) is a biologically important molecule, that accomplishes a number of useful functions in an organism. Lf can be situated in conditions associated with enrichment of reactive halogen species (asthma, infectious disease, heart-disease etс.). It was shown using spectrophotometric and fluorescence methods that HOCl and particularly HOBr lead to significant destruction of Trp residues and iron-binding capacity of Lf.
About the Authors
M. S. Terekhova
Белорусский государственный университет, Республика Беларусь
Belarus
Belarus
I. V. Gorudko
Белорусский государственный университет, Республика Беларусь
Belarus
Belarus
D. V. Grigorieva
Белорусский государственный университет, Республика Беларусь
Belarus
Belarus
I. V. Semak
Белорусский государственный университет, Республика Беларусь
Belarus
Belarus
A. V. Sokolov
ФГБНУ «Институт экспериментальной медицины», Российская Федерация
Belarus
Belarus
O. M. Panasenko
Федеральный научно-клинический центр физико-химической медицины ФМБА России, Российская Федерация
Belarus
Belarus
S. N. Cherenkevich
Белорусский государственный университет, Республика Беларусь
Belarus
Belarus
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Review
For citations:
Terekhova M.S., Gorudko I.V., Grigorieva D.V., Semak I.V., Sokolov A.V., Panasenko O.M., Cherenkevich S.N. Iron-binding property of lactoferrin in the case of inflammation. Doklady BGUIR. 2018;(7):80-84. (In Russ.)
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