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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bsuir</journal-id><journal-title-group><journal-title xml:lang="ru">Доклады БГУИР</journal-title><trans-title-group xml:lang="en"><trans-title>Doklady BGUIR</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1729-7648</issn><issn pub-type="epub">2708-0382</issn><publisher><publisher-name>БГУИР</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">bsuir-777</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>АНАЛИЗ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ОСНОВНЫХ ТРАНСПОРТНЫХ СИСТЕМ ПЛАЗМЫ КРОВИ ПАЦИЕНТОВ С ОСТРЫМИ ЛЕЙКОЗАМИ И ХРОНИЧЕСКИМ МИЕЛОЛЕЙКОЗОМ ПОСЛЕ ТРАНСПЛАНТАЦИИ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК МЕТОДОМ ФЛУОРЕСЦЕНТНОГО ЗОНДИРОВАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>ANALYSIS OF THE FUNCTIONAL STATE OF MAIN TRANSPORT SYSTEMS OF BLOOD PLASMA OF PATIENTS WITH ACUTE LEUKEMIA AND CHRONIC MYELOGENOUS LEUKEMIA AFTER TRANSPLANTATION THE HEMATOPOIETIC STEM CELLS BY FLUORESCENT PROBES METHOD</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Королик</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korolik</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Инсарова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Insarova</surname><given-names>N. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>O. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миланович</surname><given-names>Н. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Milanovich</surname><given-names>N. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усс</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Uss</surname><given-names>A. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский Государственный Медицинский Университет</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Республиканский центр гематологии и трансплантации костного мозга</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2019</year></pub-date><volume>0</volume><issue>7</issue><fpage>274</fpage><lpage>277</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Королик Е.В., Иванов А.А., Инсарова Н.И., Морозова О.М., Миланович Н.Ф., Усс А.Л., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Королик Е.В., Иванов А.А., Инсарова Н.И., Морозова О.М., Миланович Н.Ф., Усс А.Л.</copyright-holder><copyright-holder xml:lang="en">Korolik E.V., Ivanov A.A., Insarova N.I., Morozova O.M., Milanovich N.F., Uss A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://doklady.bsuir.by/jour/article/view/777">https://doklady.bsuir.by/jour/article/view/777</self-uri><abstract><p>Методом флуоресцентного зондирования установлено, что у пациентов с острым миелобластным лейкозом при проведении им высокодозной химиотерапии происходят конформационные изменения молекулы альбумина, а в посттрансплантационный период после проведения им ТГСК наблюдается уменьшение воспалительного процесса, что является благоприятным прогнозом.</p></abstract><trans-abstract xml:lang="en"><p>Using the fluorescent probes method the conformational changes in albumin have been found in case of chemotherapy high dozes applied for treatment of patients with acute myeloid leukemia, as well as the inflammatory process has been decreased after the transplantation of hematopoietic stem cells.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>флуоресцентное зондирование</kwd><kwd>лейкоз</kwd><kwd>высокодозная химиотерапия</kwd><kwd>гемопоэтические стволовые клетки</kwd><kwd>липопротеины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>a-1-кислый гликопротеин</kwd><kwd>fluorescent probe</kwd><kwd>leukemia</kwd><kwd>high-dose chemotherapy</kwd><kwd>hematopoietic stem cells</kwd><kwd>lipoproteins</kwd><kwd>a-1-acid glycoprotein</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Короленко Е.А., Королик Е.В., Королик А.К. и др. // ЖПС. 2007. 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