<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bsuir</journal-id><journal-title-group><journal-title xml:lang="ru">Доклады БГУИР</journal-title><trans-title-group xml:lang="en"><trans-title>Doklady BGUIR</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1729-7648</issn><issn pub-type="epub">2708-0382</issn><publisher><publisher-name>БГУИР</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">bsuir-746</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>МЕТАБОЛИЧЕСКИЕ И КЛИНИКО-РАДИОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ У ПАЦИЕНТОВ С СИМПТОМАТИЧЕСКОЙ ЭПИЛЕПСИЕЙ ПРИ РАЗОРВАВШИХСЯ АНЕВРИЗМАХ СОСУДОВ ГОЛОВНОГО МОЗГА</article-title><trans-title-group xml:lang="en"><trans-title>METABOLIC AND CLINICAL-RADIOLOGICAL CHANGES IN PATIENTS WITH SYMPTOMATIC EPILEPSYON THE BACKGROUND OF RUPTURED ANEURYSM IN BRAIN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нечипуренко</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Nechipurenko</surname><given-names>N. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидорович</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorovich</surname><given-names>R. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашковская</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkovskaya</surname><given-names>I. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Змачинская</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Zmachynskaya</surname><given-names>O. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василевская</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilevskaya</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Республиканский научно-практический центр неврологии и нейрохирургии</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2019</year></pub-date><volume>0</volume><issue>7</issue><fpage>144</fpage><lpage>148</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нечипуренко Н.И., Сидорович Р.Р., Пашковская И.Д., Змачинская О.Л., Василевская Л.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Нечипуренко Н.И., Сидорович Р.Р., Пашковская И.Д., Змачинская О.Л., Василевская Л.А.</copyright-holder><copyright-holder xml:lang="en">Nechipurenko N.I., Sidorovich R.R., Pashkovskaya I.D., Zmachynskaya O.L., Vasilevskaya L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://doklady.bsuir.by/jour/article/view/746">https://doklady.bsuir.by/jour/article/view/746</self-uri><abstract><p>Приведены результаты исследования метаболических и клинико-радиологических изменений у пациентов двух групп с симптоматической эпилепсией или без эпиприступов при кровоизлияниях из разорвавшихся артериальных аневризм. Полученные данные свидетельствуют о развитии нарушений гипоксического характера с активацией прооксидантных реакций в обеих группах, однако у пациентов с симптоматической эпилепсией установлено значительное снижение антиоксидантной активности ферментативных и неферментативных систем защиты клеток при повышении продукции провоспалительного цитокина ФНО-альфа в отличие от группы пациентов без эписиндрома.</p></abstract><trans-abstract xml:lang="en"><p>The results of the study of metabolic and clinical-radiological changes in patients of two groups with and without symptomatic epilepsy on the background of hemorrhages from ruptured arterial aneurysms are shown. The findings suggest that there is the development of hypoxic nature of violations with the activation of prooxidant reactions in both groups, however, in patients with symptomatic epilepsy was found a significant decrease in antioxidant activity of enzymatic and non-enzymatic cell protection systems with increasing the production of the proinflammatory cytokine TNF-alpha in contrast to the group of patients without epilepsy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная аневризма</kwd><kwd>кровоизлияние в головной мозг</kwd><kwd>симптоматическая эпилепсия</kwd><kwd>КТ-ангиография</kwd><kwd>метаболические показатели</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial aneurysm</kwd><kwd>cerebral hemorrhage</kwd><kwd>symptomatic epilepsy</kwd><kwd>CT-angiography</kwd><kwd>metabolic parameters</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Литовченко Т.А., Флорикян В.А. // Укр. вестник психоневр. 2014. Т. 22, № 3. С. 139-145.</mixed-citation><mixed-citation xml:lang="en">Литовченко Т.А., Флорикян В.А. // Укр. вестник психоневр. 2014. Т. 22, № 3. С. 139-145.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt W.E., Hess R.M. // J. Neurosurg. 1968. Vol. 28. P. 14-19.</mixed-citation><mixed-citation xml:lang="en">Hunt W.E., Hess R.M. // J. Neurosurg. 1968. Vol. 28. P. 14-19.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Drake C.G. // J. Neurosurg. 1988. Vol. 68. P. 985-986.</mixed-citation><mixed-citation xml:lang="en">Drake C.G. // J. Neurosurg. 1988. Vol. 68. P. 985-986.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Костюк В.А., Потапович А.И. // Вопр. мед. химии. 1987. № 3. С.115-118.</mixed-citation><mixed-citation xml:lang="en">Костюк В.А., Потапович А.И. // Вопр. мед. химии. 1987. № 3. С.115-118.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Костюк В.А., Потапович А.И., Ковалева Ж.В. // Вопр. мед. химии. 1990. Т.36, № 2. С. 88-91.</mixed-citation><mixed-citation xml:lang="en">Костюк В.А., Потапович А.И., Ковалева Ж.В. // Вопр. мед. химии. 1990. Т.36, № 2. С. 88-91.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Starke R.M. // Curr Neurovasc Res. 2013. Vol. 10 (3). P. 247-255.</mixed-citation><mixed-citation xml:lang="en">Starke R.M. // Curr Neurovasc Res. 2013. Vol. 10 (3). P. 247-255.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen X.L., Zhang Q., Zhao R. et. al. // Am J Physiol Heart Circ Physiol. 2004. Vol. 286 (3). P. 1001-1007.</mixed-citation><mixed-citation xml:lang="en">Chen X.L., Zhang Q., Zhao R. et. al. // Am J Physiol Heart Circ Physiol. 2004. Vol. 286 (3). P. 1001-1007.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
