This article proposes an approach for designing a general subsystem of automatic generation of questions in intelligent learning systems. The designed subsystem allows various types of questions to be automatically generated based on information from the knowledge bases and save the generated questions in the subsystem knowledge base for future use. The main part of the subsystem is the automatic generation module of questions, which allows one to generate questions of various types based on existing question generation strategies in combination with the structural characteristics of knowledge bases built using OSTIS technology. In this article, a variety of strategies for automatically generated questions are proposed, the use of which allows various types of questions to be automatically generated, such as multiple-choice questions, fill-in-the-blank questions, questions of definition interpretation and etc. The most important part of the subsystem is the knowledge base, which stores the ontology of questions, including the question instances themselves. In this article, the knowledge base is constructed based on OSTIS technical standards. The type classification of automatically generated questions was developed, as well as the subject area for storing generated questions and the corresponding ontology described in the knowledge base of the subsystem. The generated questions are stored in the subsystem knowledge base in the form of SC-code, which is the OSTIS technology standard. When testing users, these automatically generated questions are converted to the corresponding natural language form through the natural language interface. Compared with the existing approaches, the approach proposed in this article has certain advantages, and the subsystem designed using this approach can be used in various OSTISbased systems driven by OSTIS technology.