bsuirДоклады БГУИРDoklady BGUIR1729-76482708-0382БГУИРbsuir-1024Research ArticleСтатьиПРОГРАММНО-ВЫЧИСЛИТЕЛЬНЫЙ КОМПЛЕКС «ОКУНЬ-2» ДЛЯ ОЦЕНКИ МУТАЦИОННОГО ПРОФИЛЯ ГЕНОВ РЕЗИСТЕНТНОСТИ И ВИРУЛЕНТНОСТИ СЕКВЕНИРОВАННЫХ ГЕНОМОВ МИКОБАКТЕРИИ ТУБЕРКУЛЕЗА«Okun-2» software-computing complex for calculating the mutational profile of samples of the sequenced whole genomes of mycobacteria tuberculosisСпринджукМ. В.SprindzukM. V.bioinformatics_bel@yahoo.comТитовЛ. П.TitovL. P.noemail@neicon.ruСлизеньВ. В.SlizenV. V.noemail@neicon.ruСкрягинА. Е.SkryahinA. E.noemail@neicon.ruСкрягинаЕ. М.SkryahinaE. M.noemail@neicon.ruЗалуцкаяО. М.ZalutskayaO. M.noemail@neicon.ruКончицА. П.KonchitsA. P.noemail@neicon.ruОбъединенный институт проблем информатики НАН Беларуси, Республика БеларусьBelarusРНПЦ эпидемиологии и микробиологии, Республика БеларусьBelarusБелорусский государственный медицинский университет, Республика БеларусьBelarusРНПЦ фтизиатрии и пульмонологии, Республика БеларусьBelarusИнститут леса НАН Беларуси, Республика БеларусьBelarus201803062019064045Copyright © Спринджук М.В., Титов Л.П., Слизень В.В., Скрягин А.Е., Скрягина Е.М., Залуцкая О.М., Кончиц А.П., 20192019Спринджук М.В., Титов Л.П., Слизень В.В., Скрягин А.Е., Скрягина Е.М., Залуцкая О.М., Кончиц А.П.Sprindzuk M.V., Titov L.P., Slizen V.V., Skryahin A.E., Skryahina E.M., Zalutskaya O.M., Konchits A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://doklady.bsuir.by/jour/article/view/1024

Приводится описание нового программно-вычислительного комплекса, предназначенного для обработки данных полных геномов микобактерии туберкулеза человека с целью получения информации о профиле резистентности и вирулентности туберкулеза.

Authors describe a new software and computer complex designed and developed for the processing of the data of the whole genomes of mycobacterium tuberculosis with the purpose of obtaining information about the profile of tuberculosis resistance and virulence.

туберкулезгеномикаполногеномное секвенированиеантибиотикиустойчивость к противотуберкулезным лекарственным средствамбиоинформатикаtuberculosisgenomicswhole genome sequencingantibioticsresistance to anti-tuberculosis drugsbioinformaticsReferencesTransmission Electron Microscopy of XDR Mycobacterium tuberculosis Isolates Grown on High Dose of Ofloxacin / M. Arjomandzadegan [et al.] // Sci Pharm. 2017. № 1. P. 3-10.Transmission Electron Microscopy of XDR Mycobacterium tuberculosis Isolates Grown on High Dose of Ofloxacin / M. Arjomandzadegan [et al.] // Sci Pharm. 2017. № 1. P. 3-10.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery / S. Ekins [et al.] // Trends Microbiol. 2011. № 2. P. 65-74.Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery / S. Ekins [et al.] // Trends Microbiol. 2011. № 2. P. 65-74.Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis / K. Faksri [et al.] // Infect Genet Evol. 2016. № 1. P. 359-368.Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis / K. Faksri [et al.] // Infect Genet Evol. 2016. № 1. P. 359-368.PhyResSE: a Web Tool Delineating Mycobacterium tuberculosis Antibiotic Resistance and Lineage from Whole-Genome Sequencing Data / S. Feuerriegel [et al.] // J Clin Microbiol. 2015. № 6. P. 1908-1914.PhyResSE: a Web Tool Delineating Mycobacterium tuberculosis Antibiotic Resistance and Lineage from Whole-Genome Sequencing Data / S. Feuerriegel [et al.] // J Clin Microbiol. 2015. № 6. P. 1908-1914.Unipro UGENE NGS pipelines and components for variant calling, RNA-seq and ChIP-seq data analyses / O. Golosova [et al.] // PeerJ. 2014. № 2. P. e644.Unipro UGENE NGS pipelines and components for variant calling, RNA-seq and ChIP-seq data analyses / O. Golosova [et al.] // PeerJ. 2014. № 2. P. e644.CASTB (the comprehensive analysis server for the Mycobacterium tuberculosis complex): A publicly accessible web server for epidemiological analyses, drug-resistance prediction and phylogenetic comparison of clinical isolates / H. Iwai [et al.] // Tuberculosis (Edinb). 2015. № 6. P. 843-844.CASTB (the comprehensive analysis server for the Mycobacterium tuberculosis complex): A publicly accessible web server for epidemiological analyses, drug-resistance prediction and phylogenetic comparison of clinical isolates / H. Iwai [et al.] // Tuberculosis (Edinb). 2015. № 6. P. 843-844.Jain N.C. Information retrieval of tuberculosis literature in e-databases // Indian J Tuberc. 2014. № 3. P. 186-188.Jain N.C. Information retrieval of tuberculosis literature in e-databases // Indian J Tuberc. 2014. № 3. P. 186-188.Shared bioinformatics databases within the Unipro UGENE platform / I.V. Protsyuk [et al.] // J Integr Bioinform. 2015. № 1. P. 257.Shared bioinformatics databases within the Unipro UGENE platform / I.V. Protsyuk [et al.] // J Integr Bioinform. 2015. № 1. P. 257.Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools / V. Schleusener [et al.] // Scientific Reports. 2017. № 4. P. 46327.Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools / V. Schleusener [et al.] // Scientific Reports. 2017. № 4. P. 46327.KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes / A. Steiner [et al.] // BMC Genomics. 2014. № 15. P. 881.KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes / A. Steiner [et al.] // BMC Genomics. 2014. № 15. P. 881.ExpertDiscovery and UGENE integrated system for intelligent analysis of regulatory regions of genes / Y.Y. Vaskin [et al.] // In Silico Biol. 2011. № 3-4. P. 97-108.ExpertDiscovery and UGENE integrated system for intelligent analysis of regulatory regions of genes / Y.Y. Vaskin [et al.] // In Silico Biol. 2011. № 3-4. P. 97-108.

The authors declare that there are no conflicts of interest present.